August 11, 2025
Gunnar joined the lab as a rotation student. His project focuses on the possible roles of replication factors in controlling transcriptional programs.
News Archive
August 8, 2025
We were awarded a 5 year NIH/NIGMS grant to study the mechanisms of coordination of transcription and DNA replication in eukaryotic cells! The whole lab have contributed to generation of exciting preliminary data that promise great findings in the near future. Stay tuned for job opportunities!
July 25, 2025
Our Fleming Scholars Sophia and Fatima presented today the results of their projects and we can't be more proud of them. They did an amazing job and generated exciting preliminary data. We wish them all the best in their future scientific endeavors!
July 1, 2025
Anastasia joined the lab today. During her year-long traineeship, she'll investigate the interplay between transcription and replication machineries. 
June 2, 2025
Today we welcomed OMRF Fleming Scholars Sophia and Fatima in the lab. They will work on the NSF-funded project focused on the roles of conserved domains of BET proteins in transcription regulation.
May 14, 2025
A new manuscript from the lab is on bioRxiv! We evaluated the importance of all conserved domains of BET proteins and determined that the extra-terminal (ET) domain is essential for cell viability, genome-wide transcription and BET protein chromatin occupancy. Furthermore, we provided evidence that the ET domain performs these functions serving as a hub for interactions with other factors involved in transcription regulation. Specifically, we showed that the ET domain recruits coactivators TFIID and Mediator to promoters and revealed mechanistic basis for a previously reported Bdf1-TFIID interaction by identifying and validating the ET-interacting motifs on a TFIID subunit Taf7. Our findings expand current understanding of the complex biology of BET proteins and suggest the mechanisms by which cells can bypass bromodomain inhibition in pathologic states.
April 16, 2025
So happy we could contribute to this amazing story!
April 10, 2025
Lab lunch at our favourite Thai restaurant!
February 13, 2025
Today we hosted Ali Shilatifard as an invited speaker for the OMRF research forum. Very inspiring talk and feedback from a great scientist. Thank you Ali for visiting us!
February 4, 2025
Today was a Junior Scientist Day at OMRF and we had a great help in plasmid DNA isolation!
December 6, 2024
And another Holiday season at the lab!
September 29, 2024
John and his poster at the ASBMB conference Transcriptional regulation by chromatin and RNA polymerase II.
July 1, 2024
Iwona joined us today for a year-long traineeship. Iwona is finishing her Master's degree in Molecular Biotechnology at the Jagiellonian University in Poland. She will continue a project started by Agnieszka that focuses on a functional dissection of the mechanisms of BET proteins in transcription regulation.
June 27, 2024
Our farewell party for Agnieszka who is going back to Poland to finish her MS. For a full year she was our superstar and we're confident that's not the last we hear of her! Good luck Aga!
June 3, 2024
OMRF Fleming Scholars Lauren and Chance started their internship in the lab. Their summer projects will contribute to our NSF-supported investigation into the roles of conserved domains of BET proteins.
June 2, 2024
Training next generation of researchers. 
May 30, 2024
The lab was awarded a National Science Foundation grant to investigate the roles of conserved domains of BET proteins in transcription regulation. Congratulations to the whole team for collecting exciting preliminary data that supported our proposal!
May 15, 2024
Agnieszka presenting the results of her SLAM-seq experiments at our departmental retreat in the Keystone State Park. 
February 21, 2024
Lab lunch! Srividya introduces us to Indian food!
January 26, 2024
We posted our first manuscript on bioRxiv. We describe a step-by-step protocol combining rapid degradation of target proteins using AID system with quantitation of newly synthesized mRNA using SLAM-seq. We also provide an extra-cheap protocol for library preparation for less than $15 per sample. The SLAM-seq and library preparation protocols we verified both in yeast and in mammalian cell line models.
December 19, 2023
Happy Holidays!November 6, 2023
Last week Adam completed his rotation project with us and generated important data which will guide our next steps. Today we welcomed Srividya to the lab. Her rotation project will support hypothesis generation for our R35 application. Good luck Srividya!
September 2, 2023
CSHL meeting "Mechanisms of Eukaryotic Transcription". We presented our fresh and surprising data on the roles of the bromodomains and the ET domain in facilitating Bdf1 recruitment to chromatin.July 5, 2023
We're excited to welcome Agnieszka from the Jagiellonian University in Krakow, Poland! Agnieszka will work with us during her year-long traineeship at OMRF.
June 5, 2023
Productive weeks ahead with Bess and Anar joining us for several weeks! Bess (Fleming Scholar) will work on our collaborative project with the Sansam lab and Anar (OUHSC summer undergrad internship) will help us with investigating the interplay between Bdf1/2 and Swi/Snf complexes.
May 29, 2023
Last few months of hard work by Magda, John and Fathia brought a trove of preliminary data. We're excited to delve deep into it!April 10, 2023
We welcomed to the lab our first Rotation Student through the Graduate Program in Biomedical Sciences (GPiBS). During her rotation Fathia will explore the possible interplay between BET proteins Bdf1/2 and the cohesin complex in yeast cells.March 28, 2023
We had a chance to host two amazing young scientists as part of the OMRF Junior Scientist Day. Great experience and we're looking forward to participating next year!
March 11, 2023
We're officially growing mouse embryonic stem cells in the TC room - exciting new frontier to explore!
February 13, 2023
Our new toy! Now all Western blots will be a breeze (or at least we can't blame the scanner any longer:)).
January 9, 2023
Thanks to a generous support of the Oklahoma Center for Adult Stem Cell Research we just placed an order for the brand new LI-COR Odyssey DLx system which will benefit multiple labs at OMRF and OUHSC!
November 14, 2022
John joins us as an Assistant Staff Scientist!
September 12, 2022
Our lab grows with Eleanor joining us as a Research Technician!
September 1, 2022
Magda joins the lab as an Assistant Staff Scientist and we're getting ready to start some actual experiments!
August 2, 2022
The Donczew Lab officially opens on August 2, 2022! Our investigation of transcriptional regulation begins.
